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Energy, Stress & Cellular Vitality

Liposomal Methylated B-Complex delivers a full spectrum of essential B vitamins in their biologically active, methylated, or coenzyme forms in an advanced liposomal delivery system designed for enhanced absorption.*


B vitamins play a foundational role in energy production, nervous system health, stress response, and metabolic function. By supporting these core pathways, this comprehensive B-complex promotes cellular energy, cognitive function, cardiovascular health, and overall vitality.*

Supports cellular energy production*
Promotes healthy nervous system function*
Active B vitamins for methylation support*
Supports healthy stress response and homocysteine metabolism*

CoQ10 Product CoQ10 Product
CoQ10 Benefits CoQ10 Benefits
Liposomal Methylated B-Complex

Key Benefits

Energy Production & Metabolism icon

Energy Production & Metabolism

B vitamins are essential cofactors in mitochondrial energy production and the metabolism of carbohydrates, fats, and proteins. This formula supports efficient energy production and metabolic function at the cellular level.*

Nervous System & Cognitive Function icon

Nervous System & Cognitive Function

Thiamin (B1), riboflavin (B2), vitamin B6, folate (B9), and vitamin B12 support healthy nervous system structure and function and play key roles in neurotransmitter synthesis involved in focus, mental clarity, mood, sleep, and cognitive performance.*

Stress Response & Adrenal Support icon

Stress Response & Adrenal Support

Pantothenic acid (B5), vitamin B6 (P5P), and vitamin B12 support the body’s response to physical and mental stress by supporting adrenal function and balanced neurotransmitter activity.*

Methylation & Cellular Health icon

Methylation & Cellular Health

Folate (as L-5-Methyltetrahydrofolate) and vitamin B12 (as methylcobalamin) support healthy methylation processes involved in DNA synthesis, detoxification pathways, neurotransmitter production, and homocysteine metabolism.*

Cardiovascular & Red Blood Cell Support icon

Cardiovascular & Red Blood Cell Support

B vitamins support healthy homocysteine metabolism and red blood cell formation, both essential for cardiovascular health and oxygen delivery throughout the body.*

Recommended By

Top Health Experts & Pro Athletes

Dr. Mark Hyman

Dr. Mark Hyman

FOUNDER, CLEVELAND CLINIC FUNCTIONAL MEDICINE, 16x NYT BESTSELLING AUTHOR, Rho Partner, Rho Partner

Rho's targeted nutrition and cellular support align perfectly with my functional medicine approachto support healthy aging from the inside out.

Dr. Jeremy London

Dr. Jeremy London

Board Certified Cardiovascular Surgeon, Rho Partner

Rho products are built on advanced delivery technology, grounded in science, and a simple addition to my daily routine.

Dr. Kristen Holmes

Dr. Kristen Holmes

Performance Scientist, Rho Partner

Sustaining high performance is an inside-out job so I trust Rho’s evidence-based formulas to support my energy, recovery and resilience.

Jon “Bones” Jones

Jon “Bones” Jones

16x ufc champion, Rho Partner

My intense UFC career has taken a toll. I rely on Rho to support recovery, longevity, and cognitive health.

Laird Hamilton

Laird Hamilton

BIG WAVE SURFER, ENTREPRENEUR, Rho Partner

Rho’s products are exactly what I need: bioavailable, clean, trusted ingredients, and easy to take.

Gabby Reece

Gabby Reece

Host, Speaker, Author, Rho Partner

With Rho, I get clean, third-party tested products I use every day and feel good sharing with family.

Dr. Becky Campbell MD

Dr. Becky Campbell MD

Functional Medicine Physician, Rho Partner

I’m usually picky about supplements, but with Rho’s Liposomal absorption technology, I know I’m getting unmatched effectiveness.

Ken Rideout

Ken Rideout

World Champion Marathoner, Rho Partner

Rho is a core part of my routine because I feel the difference. Curcumin & NAD+ help me recover faster, stay sharp, and show up with intensity every day.

These individuals partner with Rho Nutrition as paid ambassadors, sharing their real routines and results.

Recommended By

Top Health Experts & Pro Athletes

Dr. Mark Hyman
Dr. Jeremy London
Dr. Kristen Holmes
Jon “Bones” Jones
Laird Hamilton
Gabby Reece
Dr. Becky Campbell MD
Ken Rideout
Dr. Mark Hyman

Dr. Mark Hyman

FOUNDER, CLEVELAND CLINIC FUNCTIONAL MEDICINE, 16x NYT BESTSELLING AUTHOR, Rho Partner, Rho Partner

Rho's targeted nutrition and cellular support align perfectly with my functional medicine approachto support healthy aging from the inside out.

Dr. Jeremy London

Dr. Jeremy London

Board Certified Cardiovascular Surgeon, Rho Partner

Rho products are built on advanced delivery technology, grounded in science, and a simple addition to my daily routine.

Dr. Kristen Holmes

Dr. Kristen Holmes

Performance Scientist, Rho Partner

Sustaining high performance is an inside-out job so I trust Rho’s evidence-based formulas to support my energy, recovery and resilience.

Jon “Bones” Jones

Jon “Bones” Jones

16x ufc champion, Rho Partner

My intense UFC career has taken a toll. I rely on Rho to support recovery, longevity, and cognitive health.

Laird Hamilton

Laird Hamilton

BIG WAVE SURFER, ENTREPRENEUR, Rho Partner

Rho’s products are exactly what I need: bioavailable, clean, trusted ingredients, and easy to take.

Gabby Reece

Gabby Reece

Host, Speaker, Author, Rho Partner

With Rho, I get clean, third-party tested products I use every day and feel good sharing with family.

Dr. Becky Campbell MD

Dr. Becky Campbell MD

Functional Medicine Physician, Rho Partner

I’m usually picky about supplements, but with Rho’s Liposomal absorption technology, I know I’m getting unmatched effectiveness.

Ken Rideout

Ken Rideout

World Champion Marathoner, Rho Partner

Rho is a core part of my routine because I feel the difference. Curcumin & NAD+ help me recover faster, stay sharp, and show up with intensity every day.

These individuals partner with Rho Nutrition as paid ambassadors, sharing their real routines and results.

RHO Liposomal Technology

How It Works

step 1

Encapsulation

Nutrients are enclosed within liposomes—tiny, lipid-based spheres designed to protect active ingredients.

step 2

Delivery

Liposomes transport nutrients through the digestive system, shielding them from breakdown.

step 3

Designed For Absorption

Traditional supplements break down in digestion. Our phosphatidylcholine-based liposomes act as protective carriers, supporting absorption.

step 1

Encapsulation

Nutrients are enclosed within liposomes—tiny, lipid-based spheres designed to protect active ingredients.

step 2

Delivery

Liposomes transport nutrients through the digestive system, shielding them from breakdown.

step 3

Designed For Absorption

Traditional supplements break down in digestion. Our phosphatidylcholine-based liposomes act as protective carriers, supporting absorption.

Nutrient

Liposome

All reviews are from verified buyers. Some customers received a discount on a future order for sharing their honest feedback. Reviews reflect the opinions and experiences of individual customers and may not be typical for all users.

Questions? We have answers!

Methylfolate (5-MTHF) is the active, bioavailable form of folate that your body can use immediately. Unlike synthetic folic acid, it does not require conversion by your body through the MTHFR enzyme. This makes it ideal for individuals who want more direct support for methylation, mood, homocysteine metabolism, cellular energy, and nervous system health.*

Methyl B12 (methylcobalamin) works synergistically with methylfolate in key methylation pathways that influence neurotransmitter production, DNA synthesis, red blood cell formation, and energy metabolism.*

Taking both together supports efficient methylation and balanced homocysteine levels.*

Each bottle contains 30 servings. When taken daily as directed, it will last 30 days.

Take 6 mL (just over one teaspoon) per day, or as recommended by your healthcare practitioner. You can take it directly from the spoon or mix it into cold water or juice.

Before opening:Store in a cool, dry place.

After opening: While its not required, some people like to refrigerate for taste and freshness.

Use within 75 days of opening.

Liposomal delivery encapsulates nutrients inside tiny phospholipid spheres that help protect them during digestion and support efficient absorption. This system helps your body utilize more of the active forms of folate and B12 where they’re needed most - at the cellular level.*

Genetic variations such as MTHFR can reduce the body’s ability to convert folic acid and standard B12 into their active forms. Because this formula provides pre-methylated nutrients (5-MTHF + methylcobalamin), it bypasses several conversion steps and may offer more consistent support for people who need help with folate and B12 metabolism.* That said, we always recommend consulting a licensed healthcare provider for any medical questions or personal guidance.

This formula supports:

  • Healthy methylation*
  • Cellular energy & metabolism*
  • Nervous system health & cognitive function*
  • Mood & emotional well-being*
  • Cardiovascular & homocysteine support*

Benefits vary by individual and depend on overall health, nutritional status, and consistency of use.

Methylated B vitamins are generally well tolerated. Occasionally, some people may feel more energized than expected or notice mild changes in sleep or mood when starting methylated forms. If you are sensitive to methyl donors, consider starting with a smaller amount and increasing as tolerated, or speak with your clinician.

Yes. All Rho products are designed to work synergistically. Methylfolate and B12 pair well with glutathione, magnesium, and other daily essentials. If you take prescription medications or have a medical condition, consult your healthcare professional before starting.

Absolutely. Every batch undergoes rigorous third-party testing for identity, purity, potency, and contaminants. All Rho products are produced in a cGMP-certified, FDA-registered facility with full quality documentation.

Absolutely. Every batch undergoes rigorous third-party testing for identity, purity, potency, and contaminants. All Rho products are produced in a cGMP-certified, FDA-registered facility with full quality documentation.